Build an Agent-Based Model for COVID-19 Effect of Mitigation Policies

Non-Drug Intervention (NDI) is one of the important means to prevent and control the outbreak of coronavirus disease 2019 (COVID-19), and the implementation of this series of measures plays a key role in the development of the epidemic. The purpose of this paper is to study the impact of different mitigation measures on the situation of the COVID 19, and effectively respond to the prevention and control situation in the "post-epidemic era". The present work is based on the Susceptible-Exposed-Infectious-Remove-Susceptible (SEIRS) Model, and adapted the agent-based model (ABM) to construct the epidemic prevention and control model framework to simulate the COVID-19 epidemic from three aspects: social distance, personal protection, and bed resources. The experiment results show that the above NDI are effective mitigation measures for epidemic prevention and control, and can play a positive role in the recurrence of COVID-19, but a single measure cannot prevent the recurrence of infection peaks and curb the spread of the epidemic;When social distance and personal protection rules are out of control, bed resources will become an important guarantee for epidemic prevention and control. Although the spread of the epidemic cannot be curbed, it can slow down the recurrence of the peak of the epidemic;When people abide by social distance and personal protection rules, the pressure on bed resources will be eased. At the same time, under the interaction of the three measures, not only the death toll can be reduced, but the spread of the epidemic can also be effectively curbed. © 2022 ACM.

Platform Behavior under Market Shocks: A Simulation Framework and Reinforcement-Learning Based Study

We study the behavior of an economic platform (e.g., Amazon, Uber Eats, Instacart) under shocks, such as COVID-19 lockdowns, and the effect of different regulation considerations. To this end, we develop a multi-agent simulation environment of a platform economy in a multi-period setting where shocks may occur and disrupt the economy. Buyers and sellers are heterogeneous and modeled as economically-motivated agents, choosing whether or not to pay fees to access the platform. We use deep reinforcement learning to model the fee-setting and matching behavior of the platform, and consider two major types of regulation frameworks: (1) taxation policies and (2) platform fee restrictions. We offer a number of simulated experiments that cover different market settings and shed light on regulatory tradeoffs. Our results show that while many interventions are ineffective with a sophisticated platform actor, we identify a particular kind of regulation - fixing fees to the optimal, no-shock fees while still allowing a platform to choose how to match buyers and sellers - as holding promise for promoting the efficiency and resilience of the economic system. © 2023 ACM.

AN AGENT-BASED MODELLING APPROACH FOR ASSESSING ENTREPRENEURIAL INTENTIONS AND DEVELOPMENT STRATEGIES IN THE RURAL HOSPITALITY INDUSTRY

Rural hospitality and tourism (RHT) play a key role in rural revitalization, especially due to the impact of COVID-19, with more citizens choosing to travel to the countryside for a staycation. Local SMEs, especially family-owned enterprises, make up the majority of the RHT sector, not only providing services and products to satisfy tourists, but also helping with local employment. However, entrepreneurs operating in rural areas face many challenges in terms of capital, skills and education. Hence, it is important to explore the entrepreneurial intention (EI) of local people and how policies can support or change their behaviours. Current research on the RHT industry, rarely study the EI of local people, and the literature on rural entrepreneurship concentrates on developed countries. This study therefore uses agent-based modelling to explore how locals' EI in Chongming island (China) respond to the current impact of COVID-19, and whether policies will bring about changes on the supply side of RHT sector. © SW 2023.All rights reserved

Coupling Machine Learning and Agent-Based Modeling to Characterize Contamination Sources in Water Distribution Systems for Changing Demand Regimes

Water distribution systems (WDSs) deliver clean, safe drinking water to consumers, providing an essential service to constituents. WDSs are increasingly at risk of contamination due to aging infrastructure and intentional acts that are possible through cyber-physical vulnerabilities. Identifying the source of a contamination event is challenging due to limited system-wide water quality monitoring and non-uniqueness present in solving inverse problems to identify source characteristics. In addition, changes in the expected demand patterns that are caused by, for example, social distancing during a pandemic, adoption of water conservation behaviors, or use of decentralized water sources can change the anticipated propagation of contaminant plumes in a network. This research develops a computational framework to characterize contamination sources using machine learning (ML) techniques and simulate water demands and human exposure to a contaminant using agent-based modeling (ABM). An ABM framework is developed to simulate demand changes during the COVID-19 pandemic. The ABM simulates population movement dynamics, transmission of COVID-19 within a community, decisions to social distance, and changes in demands that occur due to social distancing decisions. The ABM is coupled with a hydraulic simulation model, which calculates flows in the network to simulate the movement of a contaminant plume in the network for several contamination event scenarios. ML algorithms are applied to determine the location of source nodes. Research results demonstrate that ML using random forests can identify source nodes based on inline and mobile sensor data. Sensitivity analysis is conducted to explore the number of mobile sensors that are needed to accurately identify the source node. Rapidly identifying contamination source nodes can increase the speed of response to a contamination event, reducing the impact to the community and increasing the resiliency of WDSs during periods of changing demands. © World Environmental and Water Resources Congress 2023.All rights reserved

Bottom-up and top-down paradigms of artificial intelligence research approaches to healthcare data science using growing real-world big data.

OBJECTIVES: As the real-world electronic health record (EHR) data continue to grow exponentially, novel methodologies involving artificial intelligence (AI) are becoming increasingly applied to enable efficient data-driven learning and, ultimately, to advance healthcare. Our objective is to provide readers with an understanding of evolving computational methods and help in deciding on methods to pursue. TARGET AUDIENCE: The sheer diversity of existing methods presents a challenge for health scientists who are beginning to apply computational methods to their research. Therefore, this tutorial is aimed at scientists working with EHR data who are early entrants into the field of applying AI methodologies. SCOPE: This manuscript describes the diverse and growing AI research approaches in healthcare data science and categorizes them into 2 distinct paradigms, the bottom-up and top-down paradigms to provide health scientists venturing into artificial intelligent research with an understanding of the evolving computational methods and help in deciding on methods to pursue through the lens of real-world healthcare data.

TRACE-Omicron: Policy Counterfactuals to Inform Mitigation of COVID-19 Spread in the United States

The Omicron wave is the largest wave of COVID-19 pandemic to date, more than doubling any other in terms of cases and hospitalizations in the United States. In this paper, a large-scale agent-based model of policy interventions that could have been implemented to mitigate the Omicron wave is presented. The model takes into account the behaviors of individuals and their interactions with one another within a nationally representative population, as well as the efficacy of various interventions such as social distancing, mask wearing, testing, tracing, and vaccination. We use the model to simulate the impact of different policy scenarios and evaluate their potential effectiveness in controlling the spread of the virus. The results suggest the Omicron wave could have been substantially curtailed via a combination of interventions comparable in effectiveness to extreme and unpopular singular measures such as widespread closure of schools and workplaces, and highlight the importance of early and decisive action. © 2023 Wiley-VCH GmbH.

Predicting COVID-19 Mortalities for Patients with Special Health Conditions Using an Agent-Based Model

The spread of COVID-19 has thrown the world into a panic. We are constantly learning more about the virus every day, from how it spreads to who is more susceptible to becoming infected by different variants. Those with underlying respiratory conditions and other immunocompromised individuals need to be extra cautious regarding the virus. Many researchers have created COVID-19 trackers to detect the spread of COVID-19 around the world and show hot spots where COVID-19 cases are more prevalent. Previous work lacks the consideration of comorbidity as a factor of death rate. This work aims to create an agent-based model to predict comorbidity death rate caused by a health condition in addition to COVID-19. The model is evaluated using the symmetric mean absolute percentage error metric and proved to be very efficient. © 2023 IEEE.

Synthesis, spectroscopic, crystallographic, quantum and molecular docking investigations of cis-4,5-diphenylimidazolidine-2-thione

We present the synthesis and characterization of stereoselective thione. The synthetic procedure includes readily available starting materials and minimum side products. The reaction of meso‑stilbenediamine with carbon disulphide in the presence of strong base gave cis-4,5-diphenylimidazolidine-2-thione (DPIT) in an excellent yield. The thione compound was characterized via FT-IR and mass spectroscopy. In addition, the crystal structure of it was determined by single crystal X-rays diffraction analysis which inferred that the molecular configuration was stabilized by intramolecular π⋯π stacking interaction. The crystal packing was mainly stabilized by N-H⋯S bonding. Hirshfeld surface analysis was performed for the exploration of the intermolecular interactions. Void analysis was carried out to predict the mechanical stability. Interaction energy between the molecular pairs is calculated which showed that the dispersion energy played a dominant role in the stabilization of the crystal packing. Moreover, the quantum computational methods were used to study the molecular structure and electronic properties of entitled compound. The molecular geometries were optimized for possible thione and thiole tautomeric structures. A comparison of total energy of molecular tautomers indicates that thione tautomer possesses lower total energy which is about 20.18 Kcal/mol lower than thiole tautomer. The electronic properties of thione derivative were studied including 3-D wavefunction delocalization of highest occupied molecular orbital (HOMO) and lowest unoccupied molecular orbital (LUMO) orbitals and their orbital energy gap. The HOMO-LUMO energy gap for DPIT was found to be 4.874 eV. The delocalization of wavefunction indicates the probable presence of HOMO and HOMO-1 are mainly localized over C-S bond owing to the presence of lone pair of electrons in the sulfur atom. Additionally, the molecular docking study was also carried out for main protease (Mpro) of SARS-CoV-2. The binding energy calculation and investigation of intermolecular interactions highlighted the probable inhibition tendency of DPIT for SARS-CoV-2. The present experimental and computational studies indicate a significant potential of entitled molecule for electronic and biological perspectives.

Forecasting of COVID-19 Dynamics by Agent-Based Model

The novel coronavirus pandemic has continued to spread worldwide for more than two years. The development of automated solutions to support decision-making in pandemic control is still an ongoing challenge. This study aims to develop an agent-based model of the COVID-19 epidemic process to predict its dynamics in a specific area. The model shows sufficient accuracy for decision-making by public health authorities. At the same time, the advantage of the model is that it allows taking into account the stochastic nature of the epidemic process and the heterogeneity of the studied population. At the same time, the adequacy of the model can be improved with a more detailed description of the population and external factors that can affect the dynamics of the epidemic process. © 2023, The Author(s), under exclusive license to Springer Nature Switzerland AG.

Politicization of Science in COVID-19 Vaccine Communication: Comparing US Politicians, Medical Experts, and Government Agencies

We compare the social media discourses on COVID-19 vaccines constructed by U.S. politicians, medical experts, and government agencies, and investigate how various contextual factors influence the likelihood of government agencies politicizing the issue. Taking the political corpus and the medical corpus as two extremes, we propose a language-based definition of politicization of science and measure it on a continuous scale. By building a machine learning classifier that captures subtle linguistic indicators of politicization and applying it to two years of government agencies' Facebook posting history, we demonstrate that: 1) U.S. politicians heavily politicized COVID-19 vaccines, medical experts conveyed minimal politicization, and government agencies' discourse was a mix of the two, yet more closely resembled medical experts;' 2) increasing COVID-19 infection rates reduced government agencies' politicization tendencies;3) government agencies in Democratic-leaning states were more likely to politicize COVID-19 vaccines than those in Republican-leaning states;and 4) the degree of politicization did not significantly differ across agencies' jurisdiction levels. We discuss the conceptualization of politicization of science, the incumbency effect, and government communication as an emerging area for political communication research. [ FROM AUTHOR] Copyright of Political Communication is the property of Routledge and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full . (Copyright applies to all s.)

Scale matters: Variations in spatial and temporal patterns of epidemic outbreaks in agent-based models

Agent-based modellers frequently make use of techniques to render simulated populations more computationally tractable on actionable timescales. Many generate a relatively small number of "representative” agents, each of which is "scaled up” to represent some larger number of individuals involved in the system being studied. The degree to which this "scaling” has implications for model forecasts is an underdeveloped field of study;in particular, there has been little known research on the spatial implications of such techniques. This work presents a case study of the impact of the simulated population size, using a model of the spread of COVID-19 among districts in Zimbabwe for the underlying system being studied. The impact of the relative scale of the population is explored in conjunction with the spatial setup, and crucial model parameters are varied to highlight where scaled down populations can be safely used and where modellers should be cautious. The results imply that in particular, different geographical dynamics of the spread of disease are associated with varying population sizes, with implications for researchers seeking to use scaled populations in their research. This article is an extension on work previously presented as part of the International Conference on Computational Science 2022 (Wise et al., 2022)[1]. © 2023 The Authors

Agent-Based Social Simulation for Policy Making

In agent-based social simulations (ABSS), an artificial population of intelligent agents that imitate human behavior is used to investigate complex phenomena within social systems. This is particularly useful for decision makers, where ABSS can provide a sandpit for investigating the effects of policies prior to their implementation. During the Covid-19 pandemic, for instance, sophisticated models of human behavior enable the investigation of the effects different interventions can have and even allow for analyzing why a certain situation occurred or why a specific behavior can be observed. In contrast to other applications of simulation, the use for policy making significantly alters the process of model building and assessment, and requires the modelers to follow different paradigms. In this chapter, we report on a tutorial that was organized as part of the ACAI 2021 summer school on AI in Berlin, with the goal of introducing agent-based social simulation as a method for facilitating policy making. The tutorial pursued six Intended Learning Outcomes (ILOs), which are accomplished by three sessions, each of which consists of both a conceptual and a practical part. We observed that the PhD students participating in this tutorial came from a variety of different disciplines, where ABSS is mostly applied as a research method. Thus, they do often not have the possibility to discuss their approaches with ABSS experts. Tutorials like this one provide them with a valuable platform to discuss their approaches, to get feedback on their models and architectures, and to get impulses for further research. © 2023, Springer Nature Switzerland AG.

Agent-based mathematical model of COVID-19 spread in Novosibirsk region: Identifiability, optimization and forecasting

The problem of identification of unknown epidemiological parameters (contagiosity, the initial number of infected individuals, probability of being tested) of an agent-based model of COVID-19 spread in Novosibirsk region is solved and analyzed. The first stage of modeling involves data analysis based on the machine learning approach that allows one to determine correlated datasets of performed PCR tests and number of daily diagnoses and detect some features (seasonality, stationarity, data correlation) to be used for COVID-19 spread modeling. At the second stage, the unknown model parameters that depend on the date of introducing of containment measures are calibrated with the usage of additional measurements such as the number of daily diagnosed and tested people using PCR, their daily mortality rate and other statistical information about the disease. The calibration is based on minimization of the misfit function for daily diagnosed data. The OPTUNA optimization framework with tree-structured Parzen estimator and covariance matrix adaptation evolution strategy is used to minimize the misfit function. Due to ill-posedness of identification problem, the identifiability analysis is carried out to construct the regularization algorithm. At the third stage, the identified parameters of COVID-19 for Novosibirsk region and different scenarios of COVID-19 spread are analyzed in relation to introduced quarantine measures. This kind of modeling can be used to select effective anti-pandemic programs. © 2023 Walter de Gruyter GmbH, Berlin/Boston 2023.

An Agent-based Modeling and Simulation Tool for the Exploration of the Effects of Masks and Vaccines on COVID-19 Spread

The pandemic's complexity made it difficult to understand the epidemiological impacts of health interventions, primarily masks and vaccines. Compartmental models alone, which are frequently employed, fall short in evaluating complex systems and heterogeneity of individuals, thus limiting research on these control measures. This study aims to explore the effects of health interventions on Corona Virus Disease 2019 (COVID-19) spread using agent-based modeling and simulation. The SEIR framework of compartmental models is employed along with the specific interventions implemented with NetLogo. Exploring the different scenarios demonstrated that respirators and medical masks, for the types of masks, and Pfizer-BioNTech and Moderna, for the brands of vaccines, are the most effective in reducing infection curve peaks, total infection, and death, when used uniformly. The model can be further extended to comprehend other scenarios and combinations of different control measures for effective planning and policymaking in mitigating the effects of COVID-19. © 2022 IEEE.

MODELING AND SIMULATION FOR THE SPREAD OF COVID-19 IN AN INDIAN CITY: A CASE STUDY

We present a case study on modeling and predicting the course of Covid-19 in the Indian city of Pune. The results presented in this paper are concerned primarily with the wave of infections triggered by the Delta variant during the period between February and June 2021. Our work demonstrates the necessity for bringing together compartmental stock-and-flow and agent-based models and the limitations of each approach when used individually. Some of the work presented here was carried out in the process of advising the local city administration and reflects the challenges associated with employing these models in a real-world environment with its uncertainties and time pressures. Our experience, described in the paper, also highlights the risks associated with forecasting the course of an epidemic with evolving variants. © 2022 IEEE.

Supply Chain Network Model using Multi-Agent Reinforcement Learning for COVID-19

The COVID-19 vaccination management in Japan has revealed many problems. The number of vaccines available was clearly less than the number of people who wanted to be vaccinated. Initially, the system was managed by making reservations with age group utilizing vaccination coupons. After the second round of vaccinations, only appointments for vaccination dates were coordinated and vaccination sites were set up in Shibuya Ward where the vaccine could be taken freely. Under a shortage of vaccine supply, the inability to make appointments arose from a failure to properly estimate demand. In addition, the vaccine expired due to inadequate inventory management, resulting in the vaccine being discarded. This is considered to be a supply chain problem in which appropriate supply could not be provided in response to demand. In response to this problem, this paper examines whether it is possible to avoid shortage and stock discards by a decentralized management system for easy on-site inventory control instead of a centralized management system in real world. Based on a multi-agent model, a model was created to redistribute inventory to clients by predicting future shortage based on demand fluctuations and past inventory levels. The model was constructed by adopting the Kanto region. The validation results of the model showed that the number of discards was reduced by about 70% and out-of-stocks by about 12% as a result of learning the dispersion management and out-of-stock forecasting © 2023, International Journal of Advanced Computer Science and Applications.All Rights Reserved.

The Design and Utilisation of PanSim, a Portable Pandemic Simulator

The COVID-19 pandemic has presented a clear and present need for urgent decision making. Set in an environment of uncertain and unreliable data, and a diverse range of possible interventions, there is an obvious need for integrating HPC into workflows that include model calibration, and the exploration of the decision space. In this paper, we present the design of PanSim, a portable, performant, and productive agent-based simulator, which has been extensively used to model and forecast the pandemic in Hungary. We show its performance and scalability on CPUs and GPUs, then we discuss the workflows PanSim integrates into. We describe the heterogeneous, resource-constrained HPC environment available to us, and formulate a scheduling optimisation problem, as well as heuristics to solve them, to either minimise the execution time of a given number of simulations or to maximise the number of simulations executed in a given time frame. © 2022 IEEE.

Identifying Correlates of Emergent Behaviors in Agent-Based Simulation Models Using Inverse Reinforcement Learning

In large agent-based models, it is difficult to identify the correlate system-level dynamics with individual-level attributes. In this paper, we use inverse reinforcement learning to estimate compact representations of behaviors in large-scale pandemic simulations in the form of reward functions. We illustrate the capacity and performance of these representations identifying agent-level attributes that correlate with the emerging dynamics of large-scale multi-agent systems. Our experiments use BESSIE, an ABM for COVID-like epidemic processes, where agents make sequential decisions (e.g., use PPE/refrain from activities) based on observations (e.g., number of mask wearing people) collected when visiting locations to conduct their activities. The IRL-based reformulations of simulation outputs perform significantly better in classification of agent-level attributes than direct classification of decision trajectories and are thus more capable of determining agent-level attributes with definitive role in the collective behavior of the system. We anticipate that this IRL-based approach is broadly applicable to general ABMs. © 2022 IEEE.

Using a hybrid simulation model to assess the impacts of combined COVID-19 containment measures in a high-speed train station

In this study, we present a hybrid agent-based model (ABM) and discrete event simulation (DES) framework where ABM captures the spread dynamics of COVID-19 via asymptomatic passengers and DES captures the impacts of environmental variables, such as service process capacity, on the results of different containment measures in a typical high-speed train station in China. The containment and control measures simulated include as-is (nothing changed) passenger flow control, enforcing social distancing, adherence level in face mask-wearing, and adding capacity to current service stations. These measures are evaluated individually and then jointly under a different initial number of asymptomatic passengers. The results show how some measures can consolidate the outcomes for each other, while combinations of certain measures could compromise the outcomes for one or the other due to unbalanced service process configurations. The hybrid ABM and DES models offer a useful multi-function simulation tool to help inform decision/policy makers of intervention designs and implementations for addressing issues like public health emergencies and emergency evacuations. Challenges still exist for the hybrid model due to the limited availability of simulation platforms, extensive consumption of computing resources, and difficulties in validation and optimisation. © 2023 The Operational Research Society.

School's Out? Simulating Schooling Strategies During COVID-19

Multi-agent based systems offer the possibility to examine the effects of policies down to specific target groups while also considering the effects on a population-level scale. To examine the impact of different schooling strategies, an agent-based model is used in the context of the COVID-19 pandemic using a German city as an example. The simulation experiments show that reducing the class size by rotating weekly between in-person classes and online schooling is effective at preventing infections while driving up the detection rate among children through testing during weeks of in-person attendance. While open schools lead to higher infection rates, a surprising result of this study is that school rotation is almost as effective at lowering infections among both the student population and the general population as closing schools. Due to the continued testing of attending students, the overall infections in the general population are even lower in a school rotation scenario, showcasing the potential for emergent behaviors in agent-based models. © 2023, The Author(s), under exclusive license to Springer Nature Switzerland AG.